Kareem Hunt rushed for two touchdowns in the first half on Sunday as the Kansas City Chiefs became the only unbeaten team in the NFL with a 28-18 victory over the San Francisco 49ers in Santa Clara, Calif., in a rematch of last season's Super Bowl.

Patrick Mahomes completed 16 of 27 passes for 154 yards with two interceptions for Kansas City (6-0) but ripped off a career-high 33-yard run to set up a key fourth-quarter touchdown. The Chiefs outrushed San Francisco 184-101 and possessed the ball for more than 35 minutes while winning the rematch of last season's Super Bowl won by Kansas City.

Brock Purdy hit 17 of 31 passes for 212 yards but tossed three interceptions, two of them ending potential scoring drives in the second half. The 49ers (3-4) were missing three offensive starters by the time the game ended. Wide receivers Deebo Samuel (illness) and Brandon Aiyuk (knee) left before halftime and tackle Trent Williams was ejected late in the fourth quarter for throwing a punch.

San Francisco pulled within 14-12 with 10:29 left in the third quarter when Purdy rushed for the first of his two touchdowns from a yard out, but the 49ers failed to make the two-point conversion. They were driving for a possible go-ahead score when Purdy was picked off by Chris Roland-Wallace at the 21-yard line.

Kansas City then ripped off a 79-yard, 13-play drive that lasted nearly seven minutes. Mahomes' big run set up first-and-goal at the 4, and he scored on a fourth-down run from the 1 with 14:13 left in the game.

After Purdy's third interception, the Chiefs sealed the outcome by marching 80 yards in 6:20. Mecole Hardman peeled off an 18-yard touchdown run on a jet sweep with 3:09 remaining for an insurmountable 28-12 advantage.

Purdy added his second 1-yard scoring run at the 1:08 mark, but the 49ers couldn't tack on the two-point conversion or recover an onside kick, sealing the outcome.

Kansas City took a 14-6 advantage at the half as Hunt, who finished with 78 yards on 22 carries, scored on runs of 1 and 6 yards in the second quarter.

Anders Carlson hit field goals of 55 and 24 yards for San Francisco.

--Field Level Media