Miami at Pittsburgh 12:35 PM ET
Pittsburgh Pirates left-hander Bailey Falter will try to rediscover his May form when he opposes the visiting Miami Marlins on Wednesday afternoon in the decisive contest of a three-game series.
Chi. Cubs at Philadelphia 1:05 PM ET
Ben Brown and Jesus Luzardo are trending in different directions heading into the Wednesday matchup between the visiting Chicago Cubs and the Philadelphia Phillies.
Cincinnati at Cleveland 1:10 PM ET
The Cincinnati Reds have earned a high-five in their rivalry with the Cleveland Guardians.
Atlanta at Milwaukee 2:10 PM ET
The visiting Atlanta Braves will turn to right-hander Spencer Schwellenbach as they look to win their first series in almost a month when they face the Milwaukee Brewers in the deciding game on Wednesday.
Toronto at St. Louis 2:15 PM ET
Toronto Blue Jays pitcher Max Scherzer appears to be on track to return from his thumb injury before the end of the month.
Seattle at Arizona 3:40 PM ET
The Arizona Diamondbacks will aim for a second sweep in their past three series when they meet the slumping Seattle Mariners in the finale of a three-game set on Wednesday afternoon in Phoenix.
Athletics at LA Angels 4:07 PM ET
The Los Angeles Angels will look for their seventh victory in nine games when they host the Athletics in the finale of a three-game series on Wednesday afternoon at Anaheim, Calif.
LA Dodgers at San Diego 4:10 PM ET
Center fielder Jackson Merrill and the San Diego Padres didn't waste much time fretting over Monday night's 8-7, 10-inning loss to the Los Angeles Dodgers.
Detroit at Baltimore 6:35 PM ET
It's hard to imagine it being much better for the Detroit Tigers entering Wednesday night's game against the host Baltimore Orioles.
Washington at NY Mets 7:10 PM ET
The Washington Nationals learned about the resiliency of the New York Mets during a series between the teams in April.
Tampa Bay at Boston 7:10 PM ET
The Tampa Bay Rays will look to win a ninth consecutive Zack Littell start in the rubber game of a three-game road series against the Boston Red Sox on Wednesday night.
Texas at Minnesota 7:40 PM ET
The Texas Rangers will try to build on a season-best performance at the plate when they take on the Minnesota Twins on Wednesday night in Minneapolis.
NY Yankees at Kansas City 7:40 PM ET
One of the few blemishes on Kris Bubic's stellar season for Kansas City came against the New York Yankees.
Chi. White Sox at Houston 8:10 PM ET
Despite their 4-2 loss to the Chicago White Sox on Tuesday in the opener of a three-game series and six-game homestand, the Houston Astros have displayed an admirable measure of resilience in the face of debilitating injuries.
San Francisco at Colorado 8:40 PM ET
The San Francisco Giants apparently are more comfortable with nail-biters than blowouts.