Seattle at Chi. Cubs 2:20 PM ET
The Seattle Mariners embark on a challenging 10-game road trip, starting with the opener of a three-game interleague set on Friday against the Chicago Cubs, who sit atop the National League Central.
Texas at Pittsburgh 6:40 PM ET
A day after celebrating his 37th birthday, Jacob deGrom will try to put the Texas Rangers back on the right track when he takes the mound against rookie Mike Burrows and the host Pittsburgh Pirates to open a three-game series on Friday night.
Detroit at Tampa Bay 7:05 PM ET
Coming off a long, action-filled day of baseball, the major-league-leading Detroit Tigers visit the Tampa Bay Rays for the opener of a three-game set on Friday.
Baltimore at NY Yankees 7:05 PM ET
For about a week, the New York Yankees presented a tone of calm inside their quiet clubhouse as their woes at the plate persisted through a six-game losing streak.
Chi. White Sox at Toronto 7:07 PM ET
The Toronto Blue Jays are beginning to chirp about chasing first place in the American League East.
Atlanta at Miami 7:10 PM ET
The Atlanta Braves have every reason to smile after beginning an extended stretch against National League East foes with a resounding three-game series sweep.
NY Mets at Philadelphia 7:15 PM ET
This isn't September 2007 or September 2008 for the Philadelphia Phillies and New York Mets.
Cincinnati at St. Louis 7:15 PM ET
The Cincinnati Reds are feeling pretty good, having won four of five and nine of their past 12 games even with a loss in their most recent game.
Milwaukee at Minnesota 8:10 PM ET
Minnesota's Byron Buxton is making a case to earn an All-Star selection for the second time in his career.
Arizona at Colorado 8:40 PM ET
The Arizona Diamondbacks and Colorado Rockies are both feeling upbeat for their weekend series in Denver, but for different reasons.
Houston at LA Angels 9:38 PM ET
The visiting Houston Astros will look to continue their good fortune against the Los Angeles Angels on Friday night when the teams open a three-game series in Anaheim, Calif.
Kansas City at San Diego 9:40 PM ET
The San Diego Padres hopped on Interstate 5 late Thursday night and headed south toward home, happy to escape Los Angeles with a 5-3 win over the Dodgers that averted a series sweep.
Cleveland at Athletics 10:05 PM ET
Nick Kurtz's power display already has become the stuff of highlight reels for the Athletics just 37 games into his major-league career.
Washington at LA Dodgers 10:10 PM ET
After a successful, tension-filled run through a pair of opponents from their own division, the Los Angeles Dodgers will move out of what they considered a "gauntlet" of the schedule when they welcome the Washington Nationals on Friday night.
Boston at San Francisco 10:15 PM ET
Rafael Devers will get a visit from his former team less than a week after he was traded when the Boston Red Sox venture into San Francisco to take on the Giants in the opener of a three-game series Friday night.